Related Experiment Video
Updated: Apr 27, 2026
Translationally-Relevant Tumor Resection Model for Murine Preclinical Models of Oral Squamous Cell Carcinoma
Published on: April 3, 2026
Primary surgical therapy for locally limited oral tongue cancer
Konstantinos Mantsopoulos1, Georgios Psychogios1, Julian Künzel1
1Department of Otorhinolaryngology, Head and Neck Surgery, University of Erlangen-Nuremberg, Waldstraße 1, 91054 Erlangen, Germany.
Objectives:
The aim of this study was to assess the efficacy of primary surgical treatment in the management of locally limited oral tongue carcinoma.
Methods:
A retrospective evaluation was carried out for all patients treated with primary surgery for pT1-pT2 oral tongue carcinomas at a tertiary referral center between 1980 and 2005. All cases were assessed for disease-specific survival and local control rates in relation to T classification, N classification, infiltration depth of the primary tumor, and decision making on neck management and adjuvant therapy. The cases were additionally evaluated for the incidence of major complications and tracheotomies.
Results:
263 cases were assessed. The 5-year disease-specific survival rate was 75.2%. Positive neck disease was shown to be a significant negative prognostic factor. The occult metastasis rate was 20.2%.
Conclusions:
Primary surgical treatment is a very effective modality against T1-T2 oral tongue carcinoma, and a low rate of complications can be anticipated.
