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Imaging biomarkers or biomarker imaging?

Markus Mitterhauser1, Wolfgang Wadsak2

  • 1Radiochemistry and Biomarker Development Unit, Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna, Austria. markus.mitterhauser@meduniwien.ac.at.

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Summary

This review clarifies molecular probe imaging (MPI), distinguishing it from "imaging biomarkers." It details molecular probes and their use in imaging, with a focus on PET radiopharmaceuticals and related aspects.

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Area of Science:

  • Biomedical Imaging
  • Radiochemistry
  • Pharmacology

Background:

  • Biomarker imaging is often understood as imaging of molecular probes.
  • The term "imaging biomarkers" can cause confusion with this established concept.
  • Molecular probes (MPs) are molecules administered to organisms carrying signalling moieties.

Purpose of the Study:

  • To differentiate and clarify the term "molecular probe imaging (MPI)" versus "imaging biomarkers."
  • To highlight the fundamental concepts and distinctions in molecular probe imaging.
  • To provide a detailed overview of PET radiopharmaceuticals within this context.

Main Methods:

  • Literature review focusing on the conceptualization of molecular probe imaging.
  • Detailed discussion of Positron Emission Tomography (PET) radiopharmaceuticals.
  • Exploration of radiochemical, radiopharmacological, and legal considerations.

Main Results:

  • Establishment of "molecular probe imaging (MPI)" as the precise term for imaging molecular probes.
  • Elucidation of the characteristics and applications of molecular probes in imaging.
  • In-depth analysis of PET radiopharmaceuticals, including their development and regulatory aspects.

Conclusions:

  • Adoption of "molecular probe imaging (MPI)" is recommended to prevent ambiguity.
  • Understanding molecular probes and their imaging applications is crucial.
  • PET radiopharmaceuticals represent a key area within molecular probe imaging, with significant radiochemical and regulatory considerations.