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Updated: Apr 27, 2026
18:57
Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
Published on: October 17, 2013
45.7K
Novel prospective in colon specific drug delivery system
Vipin Bansal1, Rishabha Malviya2, Tanya Malaviya3
1Research Associate, FR&D, Akums Drugs and Pharmaceuticals Ltd, Haridwar, UK, India.
Polimery W Medycynie
|June 27, 2014
Summary
This review explores colon drug delivery systems for enhanced localized action and systemic availability of peptides and proteins. Novel technologies, including pH-sensitive polymers and natural polymers, show promise for targeted colonic drug delivery.
Area of Science:
- Pharmacology
- Drug Delivery Systems
- Gastrointestinal Research
Background:
- Targeted drug delivery to the colon is crucial for localized treatment and improved systemic absorption of sensitive drugs like peptides and proteins.
- The colon's unique physiological environment presents challenges and opportunities for drug formulation.
Purpose of the Study:
- To review novel technologies for achieving targeted drug delivery to the colon.
- To highlight the potential of pH-sensitive polymers, prodrugs, and natural polymers for colonic drug delivery.
Main Methods:
- Review of existing literature on colonic drug delivery technologies.
- Analysis of pH-sensitive polymers, prodrug strategies, and natural polymers for colon-specific release.
Main Results:
- Various novel technologies have been successfully employed for colonic drug targeting.
- pH-sensitive polymers and prodrug formulations enable targeted drug release in the colon.
- Natural polymers offer a biodegradable, less toxic, and readily available alternative for colonic drug delivery.
Conclusions:
- Targeted colonic drug delivery is achievable through advanced formulation strategies.
- Natural polymers present a promising, safe, and effective option for colon-specific drug delivery systems.
- Further research into these technologies can optimize treatment for colonic diseases and enhance peptide/protein bioavailability.
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