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Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

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Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography
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Red blood cell distribution width: reference intervals for neonates.

Robert D Christensen1, Hassan M Yaish, Erick Henry

  • 1Department of Women and Newborns, Intermountain Healthcare, McKay-Dee Hospital Center , Ogden, UT , USA .

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|June 27, 2014
PubMed
Summary
This summary is machine-generated.

Red blood cell distribution width (RDW) reference intervals in neonates are higher than in adults. High RDW values at birth suggest anemia, while low values may indicate microcytosis.

Keywords:
AnemiaRBC indicesRDWerythrocytehematocritred cell distribution width

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Area of Science:

  • Neonatal Hematology
  • Clinical Pathology

Background:

  • Red blood cell distribution width (RDW) is a measure of the variation in red blood cell size.
  • Establishing accurate reference intervals for RDW in neonates is crucial for diagnosing hematological conditions.

Purpose of the Study:

  • To establish reference intervals for RDW in neonates.
  • To utilize these intervals for improved classification of neonatal hematopathology.

Main Methods:

  • Retrospective analysis of 165,613 complete blood cell counts (CBCs) from neonates born between 2001 and 2011.
  • RDW values were analyzed based on gestational and postnatal age.
  • Correlation with reticulocyte count and focused studies on extreme RDW values were performed.

Main Results:

  • Neonatal RDW reference intervals are higher than those in older children and adults, with specific ranges provided for term, late preterm, and preterm neonates at birth.
  • RDW showed a weak positive correlation with reticulocyte count.
  • High RDW values at birth were associated with anemia due to prenatal hemorrhage or hemolysis, while low RDW values correlated with relative microcytosis.

Conclusions:

  • The established RDW reference interval at birth (15.5-20%) is essential for neonatal hematology.
  • High RDW values indicate anisocytosis, often linked to macrocytic reticulocytosis, and low values suggest relative microcytosis.
  • These findings aid in the better understanding and classification of neonatal hematopathology.