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Updated: Apr 27, 2026

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
Published on: November 15, 2013
[Pharmacological importance of orphan nuclear receptors]
Abstract:
The orphan nuclear receptors belong to the family of ligand-activated transcription factors localized in the nucleus or cytoplasm. Through them, many biological processes such as metabolism of glucose, lipids and bile acids, inflammation, tumour growth, or differentiation of cells, are controlled. From the pharmacological point of view, they play a significant role in regulating the elimination of xenobiotics from the organism. Also interesting is the possibility of xenobiotic targeting the orphan nuclear receptors for the treatment of metabolic disorders.
Insights
Orphan nuclear receptors are key regulators of metabolism and cell processes. Targeting these receptors with xenobiotics offers potential for treating metabolic disorders.
Area of Science:
- Biochemistry and Molecular Biology
- Pharmacology
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