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Neurodevelopmental disorders in children born to mothers with systemic lupus erythematosus

É Vinet1, C A Pineau2, A E Clarke3

  • 1Division of Clinical Epidemiology, McGill University Health Centre, Montreal, Canada Division of Rheumatology, McGill University Health Centre, Montreal, Canada evelyne.vinet@mail.mcgill.ca.

Lupus
|June 28, 2014
PubMed

Insights

Children born to mothers with systemic lupus erythematosus (SLE) may face higher risks for neurodevelopmental disorders. Maternal factors like antibodies, cytokines, genetics, and pregnancy complications are potential contributors to these risks in offspring.

Area of Science:

  • Reproductive immunology
  • Developmental neuroscience
  • Maternal-fetal medicine

Background:

  • Systemic lupus erythematosus (SLE) in pregnant women is associated with potential risks for offspring neurodevelopment.
  • In utero exposure to maternal autoantibodies and cytokines in SLE may impact fetal brain development.
  • Shared genetic predispositions and adverse pregnancy outcomes in SLE pregnancies are also implicated.

Purpose of the Study:

  • To review the current understanding of neurodevelopmental disorders in offspring of mothers with SLE.
  • To explore potential determinants and risk factors contributing to these disorders.

Main Methods:

  • Literature review of experimental data and clinical observations.
  • Analysis of factors including maternal immunological profiles, genetics, and pregnancy complications.

Main Results:

  • Evidence suggests maternal SLE-related factors (antibodies, cytokines) can alter fetal brain development.
  • Genetic predisposition may compromise fetal immune response to in utero insults.
  • Increased risks of adverse obstetrical outcomes and medication exposures in SLE pregnancies are noted.

Conclusions:

  • Offspring of mothers with SLE may have an elevated risk of neurodevelopmental disorders.
  • A multifactorial etiology involving maternal immunity, genetics, and pregnancy complications is likely.
  • Further research is needed to elucidate specific mechanisms and inform preventative strategies.

Keywords:
Systemic lupus erythematosusneurodevelopmental disorderspregnancy

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