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Progress on the pharmacological research of puerarin: a review
Shu-Yong Wei1, Yi Chen2, Xiao-Yu Xu2
1Pharmaceutical College of Southwest University & College of Chinese Medicine; Chongqing Engineering Research Center for Pharmacodynamics Evaluation, Chongqing 400716, China; Rongchang Campus of Southwest University, Rongchang 402460, China.
Abstract:
Contemporary pharmacological research has demonstrated that puerarin, the most important phytoestrogen extracted from Pueraria lobata(Willd.) Ohwi, has protecting functions on the cardiovascular system, nervous system, osteoporosis, liver injury, and inflammation in vivo and in vitro. Most of these research studies focused on inhibiting oxidative stress and apoptosis through regulating various bioactivators and signal pathways. Among these, superoxide dismutase (SOD), endothelial nitric oxide synthase (eNOS) and malondialdehyde (MDA), and PI3K/Akt, MAPK, and NF-κB are of great importance. The data cited in this review were mainly obtained from articles listed in PubMed and Elsevier SDOL published from 1959 to 2013, and the search term used was "puerarin".
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