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Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
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4'-Ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) inhibits HIV-1 reverse transcriptase with multiple mechanisms

Eleftherios Michailidis1, Andrew D Huber2, Emily M Ryan1

  • 1From the Christopher Bond Life Sciences Center and Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, Missouri 65211.

The Journal of Biological Chemistry
|June 28, 2014
PubMed
Summary

4'-Ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) is a potent HIV-1 inhibitor that works through multiple mechanisms, including chain termination and misincorporation. Its unique action makes HIV resistance to EFdA difficult to develop.

Keywords:
AIDSAntiviralsEFdAEnzyme InhibitorHuman Immunodeficiency Virus (HIV)NRTIsNucleoside/Nucleotide AnalogueReverse TranscriptaseReverse Transcription

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