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Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
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Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal...
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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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Vitamin D and inflammatory diseases.

Kai Yin1, Devendra K Agrawal1

  • 1Center for Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE, USA.

Journal of Inflammation Research
|June 28, 2014
PubMed
Summary

Vitamin D is crucial for immune function, impacting inflammatory diseases. Supplementation shows promise for acute infections and chronic inflammatory conditions.

Area of Science:

  • Immunology and Endocrinology
  • Nutritional Science
  • Pathophysiology of Inflammatory Diseases

Background:

  • Vitamin D is essential for calcium homeostasis.
  • Emerging evidence highlights vitamin D's role in immune modulation.
  • Low vitamin D status is linked to inflammatory diseases and infections.

Purpose of the Study:

  • To review epidemiological and interventional studies on vitamin D in inflammatory diseases.
  • To discuss the mechanisms of vitamin D's immune-regulatory effects.
  • To explore vitamin D's role in both acute and chronic inflammatory conditions.

Main Methods:

  • Review of recent epidemiological data.
  • Analysis of interventional studies.
  • Discussion of proposed biological mechanisms.
Keywords:
asthmaatherosclerosischronic kidney diseaseinflammatory bowel disease

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Main Results:

  • Lower vitamin D levels correlate with increased risk and severity of acute infections.
  • Vitamin D supplementation improves clinical outcomes in acute infections.
  • Chronic inflammatory diseases frequently present with diminished vitamin D status.

Conclusions:

  • Vitamin D plays a significant role in regulating immune and inflammatory responses.
  • Maintaining adequate vitamin D levels may be beneficial for managing inflammatory diseases.
  • Further research into vitamin D's pleiotropic effects in inflammation is warranted.