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Related Experiment Video

Updated: May 14, 2026

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way
04:45

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way

Published on: May 10, 2021

Mohs Surgery vs. Wide Local Excision for Non-Melanoma Skin Cancer: Comparing Recurrence Rates, Economic Value, and

Kimia Heidari1, Seyedshayan Shojaei2, Haiyue Jin1

  • 1School of Medicine, University of California at Irvine, Irvine, Irvine, CA 92697 USA.

Journal of Cancer Science and Clinical Therapeutics
|May 13, 2026
PubMed
Summary

Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Mohs micrographic surgery (MMS) offers better cancer control and cosmetic results than wide local excision (WLE) for non-melanoma skin cancer (NMSC). MMS is also more cost-effective, improving patient outcomes and reducing healthcare expenses.

Area of Science:

  • Dermatology and Oncology
  • Surgical Oncology
  • Health Economics

Background:

  • Non-melanoma skin cancer (NMSC), including basal-cell carcinoma (BCC) and cutaneous squamous-cell carcinoma (cSCC), is the most prevalent malignancy globally.
  • Surgical intervention is the primary treatment, with ongoing debate regarding Mohs micrographic surgery (MMS) versus wide local excision (WLE) due to differing recurrence rates, costs, and cosmetic results.

Purpose of the Study:

  • To systematically compare MMS and WLE based on long-term recurrence rates.
  • To evaluate and compare the cost-effectiveness of MMS and WLE.
  • To assess and compare the aesthetic outcomes following MMS and WLE.

Main Methods:

  • A comprehensive synthesis of prospective cohorts, registries, randomized trials, and economic models was conducted.
Keywords:
Aesthetic OutcomesEconomic ValueMohs Micrographic Surgery (MMS)Non-Melanoma Skin Cancer (NMSC)Recurrence RatesWide Local Excision (WLE)

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Last Updated: May 14, 2026

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way
04:45

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way

Published on: May 10, 2021

  • Key outcomes measured included 5-year recurrence rates, incremental cost-effectiveness ratios (ICERs), quality-adjusted life years (QALYs), and patient-reported scar assessments.

    • Main Results:

    • MMS significantly reduced 5-year recurrence for high-risk facial BCC and cSCC to ≤1% compared to 3-5% with WLE.
    • Tissue-sparing margins in MMS resulted in narrower scars and improved cosmetic outcomes, with over 90% of patients reporting excellent results versus 74% with WLE.
    • Economic analyses indicated MMS was cost-effective, dominating WLE by saving approximately $330 per patient and yielding more QALYs, with projected significant savings and QALY gains at the population level.

    Conclusions:

    • Mohs micrographic surgery (MMS) demonstrates superior oncologic control, cosmetic results, and cost-effectiveness for high-risk NMSC compared to WLE.
    • Expanding MMS availability and integrating patient-centered decision tools can enhance value-based care, leading to sustained clinical and economic advantages.