Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

7.7K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
7.7K
Cancer Survival Analysis01:21

Cancer Survival Analysis

650
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
650
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.9K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

9.4K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.4K
Genetic Screens02:46

Genetic Screens

5.6K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
5.6K
Cancer Vaccines01:30

Cancer Vaccines

974
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
974

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neuroinflammation and Mental Health in Multiple Sclerosis and Autoimmune Encephalitis: Bridging Biological Mechanisms and Psychosocial Factors.

Archives of internal medicine research·2026
Same author

Most Effective Interventions for Enhancing Neural Plasticity for Functional Recovery in Patients with Traumatic Brain Injury.

Journal of surgery and research·2026
Same author

Post-Pandemic Evaluation of Emergency Medicine Workforce Stability.

Archives of clinical and medical case reports·2026
Same authorSame journal

Mohs Surgery vs. Wide Local Excision for Non-Melanoma Skin Cancer: Comparing Recurrence Rates, Economic Value, and Aesthetic Outcomes.

Journal of cancer science and clinical therapeutics·2026
Same author

Cost-efficient and Accurate Risk Assessment Instruments in Type 2 Diabetics with Greatest Risk for Cardiovascular Disease.

Cardiology and cardiovascular medicine·2026
Same author

Shifting Career Landscapes: Analyzing the Fall in Physician-Owned Practices.

Archives of clinical and medical case reports·2026
Same journal

Role of Galectin-1 in the Pathogenesis of Melanoma.

Journal of cancer science and clinical therapeutics·2026
Same journal

The Evolving Paradigm of Esophageal and Esophagogastric Junction Adenocarcinoma: Current Insights, Emerging Therapies, and Future Directions.

Journal of cancer science and clinical therapeutics·2026
Same journal

CAR T-Cell Therapy in Cancer: Balancing Efficacy with Cardiac Toxicity Concerns.

Journal of cancer science and clinical therapeutics·2025
Same journal

Individual-Level Factors that Contribute to Delayed Cervical Cancer Diagnosis among Patients in Kenya; A Hospital-Based Assessment.

Journal of cancer science and clinical therapeutics·2025
Same journal

BRCA2 Status Alters the Effect of the P53 Reactivator HO-3867 in Ovarian Cancer Cells.

Journal of cancer science and clinical therapeutics·2025
See all related articles

Related Experiment Video

Updated: Jan 18, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.6K

Predictive Genetic Testing in the Cancer Management and Prevention.

Niayesh Najafi1, Kayvan Sasaninia1, Zoya Najafi2

  • 1Department of Translational Research, College of the Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, California, USA.

Journal of Cancer Science and Clinical Therapeutics
|January 16, 2026
PubMed
Summary
This summary is machine-generated.

Predictive genetic testing identifies disease risks, enabling early prevention and personalized treatment for hereditary conditions. This approach is crucial for reducing cancer mortality and improving survival rates in at-risk individuals.

Keywords:
Breast cancerCancer preventionColorectal cancerHereditary cancerOvarian cancerPancreatic cancerPersonalized medicinePredictive genetic testingProstate cancerScreening testUterine cancer

More Related Videos

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

7.8K
gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair
08:15

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

Published on: October 6, 2014

12.6K

Related Experiment Videos

Last Updated: Jan 18, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.6K
Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

7.8K
gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair
08:15

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

Published on: October 6, 2014

12.6K

Area of Science:

  • Medical Genetics
  • Oncology
  • Preventive Medicine

Background:

  • Predictive genetic testing identifies individuals at high risk for genetic diseases.
  • Specific gene mutations are linked to increased susceptibility to certain cancers.
  • Early detection through genetic screening can significantly reduce cancer mortality.

Purpose of the Study:

  • To review the value of preventive genetic testing in cancer prevention and control.
  • To discuss the role of hereditary mutations in cancer development.
  • To highlight the importance of genetic screening for individuals with a family history of cancer.

Main Methods:

  • Critical review of published reports on genetic testing and cancer.
  • Analysis of studies linking gene mutations to cancer susceptibility.
  • Evaluation of the impact of genetic screening on disease outcomes.

Main Results:

  • Predictive genetic testing aids in adopting prevention strategies and individualized treatment.
  • Genetic screening is essential for reducing cancer mortality and improving survival.
  • Hereditary mutations play a significant role in the development of specific cancers.

Conclusions:

  • Preventive genetic testing is a vital tool for managing hereditary diseases, particularly cancers.
  • Genetic screening empowers high-risk individuals to implement timely preventive measures.
  • Despite challenges, genetic testing offers substantial benefits in cancer control and saving lives.