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TRPV Channels in Mast Cells as a Target for Low-Level-Laser Therapy
Lina Wang1, Di Zhang2, Wolfgang Schwarz3
1Shanghai University of Traditional Chinese Medicine and Shanghai Research Center for Acupuncture and Meridians, Shanghai 201203, China. linawang1103@163.com.
Abstract:
Low-level laser irradiation in the visible as well as infrared range is applied to skin for treatment of various diseases. Here we summarize and discuss effects of laser irradiation on mast cells that leads to degranulation of the cells. This process may contribute to initial steps in the final medical effects. We suggest that activation of TRPV channels in the mast cells forms a basis for the underlying mechanisms and that released ATP and histamine may be putative mediators for therapeutic effects.
