Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

1.4K
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
1.4K
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

1.5K
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
1.5K
Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

2.2K
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
2.2K
Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

2.8K
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
 Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
2.8K
Working Memory01:24

Working Memory

1.3K
Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this...
1.3K
Aging01:26

Aging

1.1K
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Coronary microvascular function in patients with sepsis and myocardial injury: an invasive coronary physiology study.

Critical care (London, England)·2026
Same author

Linking Lipidomics to Vulnerable Coronary Plaques: A PROSPECT II Substudy.

Arteriosclerosis, thrombosis, and vascular biology·2026
Same author

Rethinking rate-related myocardial injury in sepsis: atrial fibrillation, heart rate, cardiac troponin T and long-term mortality.

Open heart·2026
Same author

Combining bacterial display and protein language models to engineer a CD69-binding affibody for molecular imaging of immune activation.

Protein engineering, design & selection : PEDS·2026
Same author

Auditory mismatch-negativity predicts response to dorsomedial prefrontal intermittent theta-burst stimulation in major depressive disorder.

Journal of affective disorders·2026
Same author

The association among glutamate, GABA, and anterior cingulate connectivity in schizophrenia spectrum disorders: Implications for symptom domains.

European psychiatry : the journal of the Association of European Psychiatrists·2026

Related Experiment Video

Updated: Apr 27, 2026

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

12.4K

Midlife memory ability accounts for brain activity differences in healthy aging.

Sara Pudas1, Jonas Persson2, Lars-Göran Nilsson3

  • 1Department of Psychology, Stockholm University, Stockholm, Sweden; Department of Integrative Medical Biology (Physiology), Umeå University, Umeå, Sweden; Umeå Center for Functional Brain Imaging, Umeå University, Umeå, Sweden.

Neurobiology of Aging
|June 29, 2014
PubMed
Summary

Midlife memory ability significantly impacts brain activity during memory tasks in older age, comparable to memory changes over time. Longitudinal data is crucial for accurately interpreting neurocognitive differences related to aging.

Keywords:
Cognitive agingEpisodic memoryIndividual differencesLongitudinal assessmentfMRI

More Related Videos

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
09:01

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

9.5K
Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
07:03

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Published on: July 31, 2019

6.4K

Related Experiment Videos

Last Updated: Apr 27, 2026

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

12.4K
A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
09:01

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

9.5K
Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
07:03

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Published on: July 31, 2019

6.4K

Area of Science:

  • Neuroscience
  • Cognitive Aging
  • Neuroimaging

Background:

  • Individual differences in memory in older adults are linked to hippocampal and prefrontal cortex function.
  • The contribution of cognitive abilities in youth to later-life cognitive and neuroimaging measures remains unclear.

Purpose of the Study:

  • To investigate the influence of midlife memory ability and age-related memory change on memory-related brain activity (BOLD-signal variability).
  • To compare the predictive power of past memory levels versus memory change on current neurocognitive measures.

Main Methods:

  • Utilized data from a longitudinal population-based aging study with 203 participants aged 55-80 years.
  • Employed hierarchical regression analyses to assess the variance explained by midlife memory ability and memory change.
  • Focused on brain activity during memory encoding, specifically in the prefrontal cortex and hippocampus.

Main Results:

  • Midlife memory ability (assessed 15-20 years prior) explained significant variance in BOLD-signal variability in the left inferior prefrontal cortex and bilateral hippocampus.
  • Memory change estimates were more sensitive than current memory levels in identifying frontal regions related to age-related memory decline.
  • Past memory ability was as influential as memory change in explaining current brain activity patterns.

Conclusions:

  • Interpreting current neurocognitive differences solely as age-related changes can be misleading without longitudinal data.
  • Longitudinal measures of cognitive change offer enhanced sensitivity for understanding age-related alterations in brain function.
  • Both baseline cognitive status and longitudinal change are important factors in cognitive aging research.