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Updated: Apr 27, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Combined reduced forced expiratory volume in 1 second (FEV1) and peripheral artery disease in sedentary elders with
Carlos A Vaz Fragoso1, Fang-Chi Hsu2, Tina Brinkley3
1Clinical Epidemiology Research Center, VA Connecticut, West Haven, CT; Department of Medicine, Yale School of Medicine, New Haven, CT.
Objectives:
Because they are potentially modifiable and may coexist, we evaluated the combined occurrence of a reduced forced expiratory volume in 1 second (FEV1) and peripheral artery disease (PAD), including its association with exertional symptoms, physical inactivity, and impaired mobility, in sedentary elders with functional limitations.
Design:
Cross sectional.
Setting:
Lifestyle Interventions and Independence in Elder (LIFE) Study.
Participants:
A total of 1307 sedentary community-dwelling persons, mean age 78.9, with functional limitations (Short Physical Performance Battery [SPPB] <10).
Measurements:
A reduced FEV1 was defined by a z-score less than -1.64 (
Results:
A combined reduced FEV1 and PAD was established in 6.0% (78/1307) of participants. However, among those who had a reduced FEV1, 34.2% (78/228) also had PAD, whereas 20.8% (78/375) of those who had PAD also had a reduced FEV1. The 2 combined conditions were associated with exertional dyspnea (adjusted odds ratio [adjOR] 2.59 [1.20-5.60]) and slow gait speed (adjOR 3.15 [1.72-5.75]) but not with exertional leg symptoms, high sedentary time, and moderate-to-severe mobility impairment.
Conclusions:
In sedentary community-dwelling elders with functional limitations, a reduced FEV1 and PAD frequently coexisted and, in combination, were strongly associated with exertional dyspnea and slow gait speed (a frailty indicator that increases the risk of deleterious outcomes).
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