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Updated: Apr 27, 2026

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
Published on: May 16, 2025
Mesalamine treatment mimicking relapse in a child with ulcerative colitis
Iva Hojsak1, Ana M Pavić, Sanja Kolaček
1Referral Center for Pediatric Gastroenterology and Nutrition, Children's Hospital Zagreb, Zagreb, Croatia, ivahojsak@gmail.com.
Background:
There are reports on mesalamine-induced bloody diarrhea mimicking ulcerative colitis (UC) relapse, mostly in adults.
Methods:
Herein we present a case of a child with UC who developed relapse of hemorrhagic colitis related to mesalamine.
Results:
A 10-year-old girl developed severe symptoms mimicking UC relapse 3 weeks after introduction of mesalamine therapy. After mesalamine was withdrawn, her symptoms improved, but deteriorated again during the challenge of mesalamine despite concomitant use of corticosteroids.
Conclusion:
This is the first case report on such a young child during the concomitant use of corticosteroids.
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