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Updated: Apr 27, 2026
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Quantification of Cerebral Vascular Architecture using Two-photon Microscopy in a Mouse Model of HIV-induced Neuroinflammation
Published on: January 12, 2016
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Human immunodeficiency virus-associated stroke: an aetiopathogenesis study.
Summary
Stroke is frequently the initial sign of human immunodeficiency virus (HIV) infection, particularly in younger individuals. Early HIV screening is crucial for stroke patients to determine the underlying cause and guide treatment.
Area of Science:
- Neurology
- Infectious Diseases
- Epidemiology
Background:
- Stroke is a significant concern in patients with human immunodeficiency virus (HIV).
- Understanding the specific characteristics and causes of stroke in HIV-positive individuals is essential for effective management.
- The etiopathogenesis of stroke in the context of HIV infection requires further elucidation.
Purpose of the Study:
- To characterize the nature of stroke in patients with HIV.
- To investigate the underlying etiopathogenesis of HIV-associated stroke.
- To determine the frequency of stroke as an initial presentation of HIV infection.
Main Methods:
- A retrospective study was conducted on 19 patients diagnosed with HIV-associated stroke.
- Data collected included HIV transmission, stroke risk factors, antiretroviral therapy (ART) status, and clinical history.
- Comprehensive hematological, serological, cerebrospinal fluid (CSF), and neuroradiological investigations were performed.
Main Results:
- Stroke was the first presentation of HIV in 78.94% of patients; 16.67% experienced recurrent cerebrovascular accidents.
- Cerebral infarction was observed in 89.47% of cases, with 5.26% experiencing hemorrhage.
- Opportunistic infections of the central nervous system (CNS) were present in 47.36% of patients; indeterminate etiologies (coagulopathy, vasculopathy) were found in 36.84%.
Conclusions:
- Stroke is increasingly recognized as an initial manifestation of HIV infection.
- Screening for HIV in young stroke patients is recommended.
- Further investigation into the specific mechanisms of stroke in HIV-infected individuals is warranted.
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