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Updated: Jun 19, 2026

Microbiological Rapid On-Site Evaluation for Pulmonary Infectious Diseases

Microbiological Rapid On-Site Evaluation for Pulmonary Infectious Diseases

Published on: March 1, 2024

Penicillium morneffei, an emerging AIDS-related pathogen--a RIMS study.

S Bhagyabati Devi¹, Th Shanti Devi, Robinson Ningshen

¹Department of Medicine, Regional Institute of Medical Sciences, Imphal 795004.

Journal of the Indian Medical Association

|October 9, 2009

Summary

This summary is machine-generated.

Penicilliosis, a disseminated Penicillium marneffei infection, is an opportunistic pathogen in HIV-infected individuals. Early diagnosis and treatment with amphotericin B and itraconazole improve survival rates.

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Live Imaging of Antifungal Activity by Human Primary Neutrophils and Monocytes in Response to A. fumigatus

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Published on: April 19, 2017

Area of Science:

Medical Mycology
Infectious Diseases
HIV/AIDS Research

Background:

Penicillium marneffei is an emerging opportunistic pathogen in immunocompromised individuals.
Disseminated penicilliosis is a significant concern in Human Immunodeficiency Virus (HIV)-infected populations.

Purpose of the Study:

To investigate the clinical, laboratory, and therapeutic characteristics of HIV-infected patients with disseminated Penicillium marneffei infection.
To highlight the importance of considering penicilliosis in the differential diagnosis of febrile illnesses in HIV patients.

Main Methods:

Retrospective study of 27 HIV-infected patients diagnosed with penicilliosis.
Diagnosis confirmed by microscopy and fungal culture.
CD4+ T-cell counts assessed using flow cytometry.

Main Results:

The majority of patients were male (23/27), with ages ranging from 20 to 54 years (mean 31.5).
Common clinical manifestations included fever, weight loss, anemia, and characteristic skin lesions.
All patients presented with low CD4+ T-cell counts, indicating significant immunosuppression.
Intravenous amphotericin B followed by oral itraconazole demonstrated excellent treatment response.

Conclusions:

Penicillium marneffei is a critical opportunistic pathogen in HIV-infected individuals in Manipur.
Penicilliosis should be suspected in patients with unexplained fever, low CD4 counts, and molluscum contagiosum-like skin lesions.
Prompt diagnosis and appropriate antifungal therapy are crucial for improving patient survival.