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Related Concept Videos

Telomeres and Telomerase02:41

Telomeres and Telomerase

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In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded...
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Replicative Cell Senescence02:15

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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
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Therapeutic Drug Monitoring: Affecting Factors01:29

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Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
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Updated: Apr 27, 2026

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
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Telomerase modulation in therapeutic approach.

Aleksandra Romaniuk, Przemyslaw Kopczynski, Krzysztof Ksiazek

  • 1Poznan University of Medical Sciences, Department of Clinical Chemistry and Molecular Diagnostics, Przybyszewskiego 49 Str., 60-355 Poznan, Poland. blazejr@ump.edu.pl.

Current Pharmaceutical Design
|July 1, 2014
PubMed
Summary
This summary is machine-generated.

Telomerase, an enzyme enabling cancer cell immortality, is a promising target for novel cancer therapies. Inhibiting telomerase can lead to cancer cell death and enhance chemotherapy effectiveness.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Telomerase synthesizes telomeric repeats (5'-TTAGGG-3') at chromosome ends, preventing cellular aging.
  • Telomerase is highly active in approximately 85% of human tumors, conferring immortality to cancer cells.
  • This cancer-specific activity makes telomerase a potential therapeutic target for adjuvant cancer treatment.

Purpose of the Study:

  • To investigate pathways and mechanisms for telomerase inhibition to induce cancer cell death.
  • To evaluate the potential of anti-telomerase strategies in sensitizing tumor cells to chemotherapy.
  • To explore the implications of telomerase induction as a therapeutic approach.

Main Methods:

  • Review of in vitro and preclinical studies on telomerase inhibition.
  • Analysis of molecular pathways targeted for telomerase downregulation.
  • Examination of potential therapeutic applications and side effects.

Main Results:

  • Telomerase inhibition leads to cancer cell death.
  • Anti-telomerase strategies show promise in sensitizing cancer cells to chemotherapeutic agents.
  • Telomerase downregulation has potential side effects that require careful consideration.

Conclusions:

  • Targeting telomerase is a viable strategy for cancer therapy, potentially enhancing existing treatments.
  • Understanding telomerase regulation is crucial for developing effective anti-cancer therapies.
  • Telomerase induction may also offer novel therapeutic avenues in oncology.