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Updated: Apr 27, 2026

Isolation of Lamina Propria Mononuclear Cells from Murine Colon Using Collagenase E
Published on: September 26, 2019
Indolent systemic mastocytosis in a patient with ileocolitis
Georgios Chrysakopoulos1, Maria Demonakou2, Stelios Papasavvas1
1Gastroenterology Department of 1 I.K.A. Hospital - Present address: Gastroenterology Clinic, General and Oncology Hospital of Kifissia Agioi Anargyroi (Georgios Chrysakopoulos, Stelios Papasavvas, Andreas Koutsoumpas, Georgios Mylonas, Vassilios Tzias), Athens, Greece.
Abstract:
Systemic mastocytosis is a clonal disorder of the mast cell and its progenitor cell. It is a rare disorder with unknown incidence in Greece, with an estimate of 2 cases per year in Great Britain. We present a case of an asymptomatic, 72-year-old man who was found to have ileocolitis on endoscopy. Histology revealed mast cells in lamina propria >15 HPF and biochemistry showed high levels of serum total tryptase. Molecular testing was positive for the mutation Asp816Val in exon 17 of c-kit gene. The patient met one major and two minor criteria for the diagnosis of systemic indolent mastocytosis (according to WHO classification). He has been treated prophylactically with H1- and H2-histamine receptor antagonists and remains asymptomatic.
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