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Natriuretic peptides in heart failure with preserved ejection fraction

A Mark Richards1, James L Januzzi2, Richard W Troughton3

  • 1Cardiac Department, Cardiovascular Research Institute, National University Heart Centre, National University of Singapore, 1E Kent Ridge Road, NUHS Tower Block, Level 9, Singapore 119228, Singapore; Department of Medicine, Christchurch Heart Institute, University of Otago, Christchurch, 2 Riccarton Avenue, Christchurch 8140, New Zealand.

Heart Failure Clinics
|July 1, 2014
PubMed

Insights

Cardiac natriuretic peptides (NPs) aid heart failure (HF) management. This review focuses on the specific evidence and application of NPs in heart failure with preserved ejection fraction (HFPEF).

Area of Science:

  • Cardiology
  • Biomarkers
  • Heart Failure Research

Background:

  • Effective heart failure (HF) management relies on timely diagnosis, risk stratification, and treatment optimization.
  • Cardiac natriuretic peptides (NPs) are established biomarkers in general HF care.
  • Limited data exist on NP utility specifically in heart failure with preserved ejection fraction (HFPEF).

Purpose of the Study:

  • To review the existing evidence for the use of natriuretic peptides (NPs) in HFPEF.
  • To clarify the role and application of NPs in the evaluation and management of HFPEF patients.

Main Methods:

  • Literature review of studies investigating natriuretic peptides (NPs) in heart failure with preserved ejection fraction (HFPEF).
  • Synthesis of data on NP performance and clinical utility in HFPEF diagnosis, risk stratification, and treatment guidance.

Main Results:

  • Evidence suggests NPs are valuable in assessing HFPEF, though less extensively studied than in HFREF.
  • NPs can aid in differentiating HFPEF from other conditions and in risk stratification.
  • Optimal therapeutic strategies guided by NPs in HFPEF require further investigation.

Conclusions:

  • Natriuretic peptides (NPs) show promise as diagnostic and prognostic tools in heart failure with preserved ejection fraction (HFPEF).
  • Further research is needed to define the best clinical applications and therapeutic implications of NPs in HFPEF management.

Keywords:
B-type natriuretic peptideCardiac natriuretic peptidesDiagnosisHeart failureN-terminal prohormone B-type natriuretic peptidePrognosis

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