Cellular behavior as a dynamic field for exploring bone bioengineering: a closer look at cell-biomaterial interface
Sara Gemini-Piperni1, Esther Rieko Takamori2, Suelen Cristina Sartoretto3
1Laboratório de Bioensaios e Dinâmica Celular, Depto. Química e Bioquímica, Instituto de Biociência, Universidade Estadual Paulista, UNESP, Campus Botucatu, Botucatu, SP, Brazil; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Biomaterials and bone bioengineering are crucial for healing major bone injuries. Tissue engineering, combining various scientific fields, aims to develop advanced materials for bone regeneration and predict cell-material interactions.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Tissue Engineering
Background:
- Bone tissue possesses natural regenerative capabilities for minor injuries.
- Major bone lesions necessitate biomaterials for tissue substitution and integration.
- Increasing life expectancy drives demand for regenerative medicine in dentistry and orthopedics.
Purpose of the Study:
- To review tissue bioengineering concepts for bone regeneration.
- To highlight critical biological parameters for biomaterial development.
- To explore intracellular signal transduction for predicting cell-material interactions in vitro.
Main Methods:
- Literature review of tissue bioengineering and biomaterials.
- Discussion of cellular and molecular biology advancements.
- Focus on intracellular signal transduction pathways.
Main Results:
- Biomaterials are essential for significant bone defect repair.
- Tissue engineering integrates multiple disciplines to create functional bone tissue.
- Intracellular signaling offers a novel approach to assess biomaterial efficacy.
Conclusions:
- Advancements in biomaterials, gene therapy, and tissue engineering hold promise for future bone healing.
- Understanding biological parameters is key to designing effective bone regeneration materials.
- Predictive in vitro models using signal transduction can guide regenerative medicine development.
Related Concept Videos
01:31Bone Remodeling and Repair
01:40Bone Remodeling
01:29The Extracellular Matrix
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
01:42The Extracellular Matrix