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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
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The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
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Genomic resources notes accepted 1 April 2014 - 31 May 2014.

, Marinela Contreras, José de la Fuente

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    Researchers have made a global transcriptome comparison of Lyme disease tick vectors, Ixodes scapularis and Ixodes ricinus, publicly available. This data aids in understanding tick biology and Lyme disease transmission dynamics.

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    Area of Science:

    • Genomics
    • Vector Biology
    • Epidemiology

    Background:

    • Lyme disease is a significant public health concern transmitted by ticks.
    • Understanding the genetic makeup of tick vectors is crucial for disease control.
    • Ixodes scapularis and Ixodes ricinus are primary vectors for Borrelia burgdorferi, the causative agent of Lyme disease.

    Purpose of the Study:

    • To document the public availability of a global transcriptome comparison.
    • To provide a valuable resource for researchers studying Lyme disease vectors.
    • To facilitate comparative analyses between key tick species.

    Main Methods:

    • Transcriptome sequencing of Ixodes scapularis and Ixodes ricinus.
    • Bioinformatic analysis of gene expression profiles.
    • Data compilation for public accessibility.

    Main Results:

    • A comprehensive global transcriptome dataset has been generated.
    • Comparative transcriptomic data between the two tick species is now publicly accessible.
    • This resource enables detailed molecular-level comparisons of tick biology.

    Conclusions:

    • The public release of this transcriptome data represents a significant advancement for Lyme disease research.
    • This resource will accelerate the discovery of novel targets for vector control and disease prevention.
    • Comparative transcriptomics provides insights into the evolution and function of genes in tick vectors.