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Updated: Apr 27, 2026

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice
Published on: March 17, 2014
Burkholderia cepacia complex isolation in non-polypoid chronic rhinosinusitis
Giancarlo Ottaviano1, Claudia Staffieri2, Niccolò Favaretto1
1Department of Neurosciences, Otolaryngology Section, University of Padova, Padova, Italy.
Purpose:
Burkholderia cepacia complex (Bcc) infections of the head and neck have been infrequently reported in immunocompetent patients, while their association with cystic fibrosis is quite well known. One of the main problems associated with Bcc is their intrinsic resistance to most clinically-available antimicrobials. Bcc has already been isolated in sinonasal polyposis, while here we report for the first time on its isolation in patients with chronic rhinosinusitis (CRS) but no nasal polyposis.
Materials And Methods:
Thirty-four consecutive surgically-treated CRS patients without cystic fibrosis were recruited.
Results:
Bcc was isolated in 4 cases of CRS without polyposis, and in another case in sinonasal polyposis. All tested Bcc strains isolated in non-polypotic CRS were resistant to ciprofloxacin, amikacin, ertapenem, amoxicillin/clavulanate, cefotaxime, and gentamicin.
Conclusions:
The novel finding of Bcc species in CRS without polyposis as well suggests that the mechanism by which these bacteria adhere to the epithelium of the upper respiratory tract may be important in the host's colonization.
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