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Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection
Published on: November 7, 2018
Hepatitis B virus lineages in mammalian hosts: potential for bidirectional cross-species transmission
Cibele R Bonvicino1, Miguel A Moreira1, Marcelo A Soares1
1Cibele R Bonvicino, Miguel A Moreira, Marcelo A Soares, Genetics Division, Instituto Nacional de Câncer, Rio de Janeiro, RJ 20231-050, Brazil.
Abstract:
The hepatitis B virus (HBV) is a cosmopolitan infectious agent currently affecting over 350 million people worldwide, presently accounting for more than two billion infections. In addition to man, other hepatitis virus strains infect species of several mammalian families of the Primates, Rodentia and Chiroptera orders, in addition to birds. The mounting evidence of HBV infection in African, Asian and neotropical primates draws attention to the potential cross-species, zoonotic transmission of these viruses to man. Moreover, recent evidence also suggests the humans may also function as a source of viral infection to other mammals, particularly to domestic animals like poultry and swine. In this review, we list all evidence of HBV and HBV-like infection of nonhuman mammals and discuss their potential roles as donors or recipients of these viruses to humans and to other closely-related species.
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