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Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

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Augmentation procedures using bone substitute materials or autogenous bone - a systematic review and meta-analysis.

Bilal Al-Nawas, Eik Schiegnitz

European Journal of Oral Implantology

|July 1, 2014

Summary

Bone substitute materials (BSM) show comparable implant survival rates to autologous bone (AB) in jaw augmentation. This systematic review found no significant difference, suggesting BSM is a viable alternative to AB for dental bone grafting procedures.

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Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts

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Published on: December 22, 2015

Area of Science:

Oral and Maxillofacial Surgery
Biomaterials Science
Dental Implantology

Background:

Bone substitute materials (BSM) offer a simpler alternative to autologous bone (AB) for grafting procedures.
Augmentation of the edentulous jaw is crucial for dental implant success.
Evaluating the efficacy of BSM versus AB is essential for optimizing treatment outcomes.

Purpose of the Study:

To systematically review and meta-analyze the influence of BSM compared to AB on treatment success in augmentation procedures of the edentulous jaw.
To compare implant survival rates between BSM and AB in maxillary sinus floor augmentation (MSFA) and alveolar ridge augmentation.
To determine if autologous bone is superior to bone substitute materials in these procedures.

Main Methods:

Systematic literature review and meta-analysis of studies published between 2000 and early 2014.
Inclusion of studies with a mean follow-up of at least 10 months.
Analysis focused on maxillary sinus floor augmentation and vertical/lateral alveolar ridge augmentation, excluding guided bone regeneration for minor defects.

Main Results:

For MSFA, implant survival rates were 98.6% (BSM), 88.6% (BSM+AB), and 97.4% (AB). Meta-analysis showed a trend favoring BSM but was not statistically significant.
For ridge augmentation, implant survival rates were 97.4% (BSM), 100% (BSM+AB), and 98.6% (AB). Meta-analysis revealed no statistically significant difference between BSM and AB.
No statistically significant difference in implant survival was found between BSM and AB for either MSFA or ridge augmentation.

Conclusions:

Implant survival in MSFA and alveolar ridge augmentation appears independent of the biomaterial used (BSM or AB).
Current literature does not provide evidence that autologous bone is superior to bone substitute materials for these procedures.
Limitations include the influence of defect size and regenerative capacity, which are not well-described in the existing literature.