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[Disseminated intravascular coagulation in solid tumours].

François Régis Ferrand1, Carine Garcia-Hejl2, Yassine Moussaid3

  • 1Hôpital du Val-de-Grâce, département d'oncologie-radiothérapie, boulevard du Port-Royal, 75005 Paris, France, Institut Gustave Roussy, département d'anesthésie-réanimation, Villejuif, France.

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Summary
This summary is machine-generated.

Disseminated intravascular coagulation (DIC) is a complex hemostasis disorder linked to tumors. This review clarifies paraneoplastic DIC diagnosis and management in solid tumors, including new patient data.

Keywords:
cancerdisseminated intravascular coagulationparanéoplastic syndrom

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Area of Science:

  • Oncology
  • Hematology
  • Pathophysiology

Background:

  • Disseminated intravascular coagulation (DIC) is a serious hemostasis disorder frequently associated with cancer.
  • The diagnosis and management of cancer-associated DIC, particularly paraneoplastic DIC, remain poorly defined.
  • Solid tumors represent a significant context for DIC development.

Purpose of the Study:

  • To review disseminated intravascular coagulation (DIC) associated with solid tumors.
  • To focus on the pathophysiological mechanisms and therapeutic strategies for paraneoplastic DIC.
  • To present data from a retrospective patient series to illustrate epidemiological, clinical, and prognostic features.

Main Methods:

  • Literature review of DIC in solid tumors.
  • Analysis of pathophysiological and therapeutic aspects.
  • Retrospective analysis of a patient cohort with solid tumors and DIC.

Main Results:

  • Paraneoplastic DIC presents complex diagnostic and management challenges.
  • The review synthesizes current understanding of DIC pathophysiology in cancer.
  • Retrospective data highlight epidemiological, clinical, and prognostic factors in tumor-associated DIC.

Conclusions:

  • Improved understanding of paraneoplastic DIC is crucial for patient outcomes.
  • Further research is needed to refine diagnostic criteria and therapeutic guidelines.
  • This work provides insights into managing DIC in the context of solid tumors.