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Association between CD14 gene polymorphisms and cancer risk: a meta-analysis
Jun Wang1, Xufeng Guo1, Shijie Yu1
1Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, People's Republic of China.
Plos One
|July 1, 2014
Summary
The CD14 gene -260C/T polymorphism may increase gastric cancer risk in individuals infected with Helicobacter pylori. Further research is needed to confirm this association between CD14 gene variants and cancer susceptibility.
Area of Science:
- Genetics
- Oncology
- Epidemiology
Background:
- CD14 gene polymorphisms (-260C/T and -651C/T) are linked to cancer susceptibility.
- Previous studies on this association have yielded inconclusive results.
Purpose of the Study:
- To investigate the association between CD14 gene polymorphisms (-260C/T and -651C/T) and cancer risk.
- To clarify the role of these polymorphisms in cancer development.
Main Methods:
- A meta-analysis of eligible case-control studies published up to March 2014.
- Searched major databases: PubMed, Web of Science, CNKI, and WanFang.
- Pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated using fixed- or random-effects models.
Main Results:
- Included 17 studies with 4198 cases and 4194 controls for -260C/T, and 3 studies with 832 cases and 1190 controls for -651C/T.
- No significant overall association was found between CD14 polymorphisms and cancer risk.
- A subgroup analysis revealed that the CD14 -260C/T polymorphism might increase gastric cancer risk in H. pylori-infected individuals.
Conclusions:
- The CD14 -260C/T polymorphism may elevate gastric cancer risk specifically in H. pylori-infected individuals.
- Further large-scale, well-designed studies are necessary to validate these findings.
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