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Updated: Apr 27, 2026
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
38.4K
Understanding therapeutic pathways and comorbidities in psoriasis.
Kenneth B Gordon1, Bruce E Strober2
1Professor of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Seminars in Cutaneous Medicine and Surgery
|July 1, 2014
Summary
Psoriasis is an immune-mediated systemic disease affecting skin and joints. New biologic therapies target its immunologic pathways, expanding treatment options and addressing associated health risks.
Area of Science:
- Immunology
- Dermatology
- Rheumatology
Background:
- Psoriasis is increasingly understood as a systemic immune-mediated disease with cutaneous and joint manifestations.
- Previously, treatments focused on keratinocyte proliferation, but now target underlying immunologic pathways.
- Biologic therapies, such as tumor necrosis factor inhibitors, represent a significant advancement in psoriasis treatment.
Purpose of the Study:
- To review the current understanding of psoriasis as an immunologic disease.
- To highlight the evolution of psoriasis treatment strategies.
- To discuss emerging pathophysiologic pathways and associated health risks.
Main Methods:
- Literature review of recent research on psoriasis pathophysiology and treatment.
- Analysis of the role of immunologic pathways in disease expression.
- Examination of comorbidities and health risks associated with psoriasis.
Main Results:
- Psoriasis treatment has shifted towards targeting specific immunologic pathways.
- Biologic medications targeting tumor necrosis factor and other immune mediators are effective.
- Research has identified new pathophysiologic pathways for potential therapeutic targets.
- Psoriasis is linked to significant health risks and comorbid inflammatory diseases, impacting quality of life.
Conclusions:
- Psoriasis is a complex systemic immune disease requiring multifaceted treatment approaches.
- Targeting immunologic pathways has revolutionized psoriasis therapy.
- Further research into novel pathways and associated risks is crucial for comprehensive patient care.
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