[Initial experience with autologous thrombocytes labeled with 111indium-oxine]

Area of Science:

• Nuclear Medicine
• Hematology
• Medical Imaging

Context:

• Autologous platelet labeling is crucial for various diagnostic procedures.
• Existing methods may have limitations in accessibility or effectiveness.
• Nuclear medicine departments require reliable techniques for patient care.

Purpose:

• To describe a modified method for separating and labeling autologous platelets using 111indium-oxine.
• To evaluate the effectiveness, yield, and viability of labeled platelets.
• To explore the clinical applications of this method in detecting thrombosis and assessing kidney transplant rejection.

Summary:

• A modified 111indium-oxine labeling technique for autologous platelets was developed and implemented.
• The method demonstrated high labeling effectiveness (79.5%) and preserved platelet aggregating capacity.
• Scintigraphy with labeled platelets showed potential for detecting intracardial/arterial thrombosis and assessing kidney transplant status.

Impact:

• The described method is implementable in standard Czechoslovak nuclear medicine departments.
• Preserved platelet viability confirmed by in vitro aggregation tests.
• Demonstrated clinical utility in identifying thrombosis and evaluating kidney transplant complications.