Metabolomic biomarkers: their role in the critical path

Global metabolic profiling is being applied to identify biomarkers of health. Some small molecules are exquisitely sensitive indicators of health status. Metabolic profiling analyses are being used to determine biomarkers of drug safety and effectiveness as well as disease diagnosis and prognosis including organ transplant rejection. To understand the mechanism(s) of drug toxicity and disease, a systems biology approach that considers the information generated from metabolic profiling, genetics, transcriptomics and proteomics research paradigms is necessary. This will allow for a better understanding of the mechanism(s) of drug interactions and disease while possibly identifying susceptible populations, an important goal in the move toward personalized medicine.: