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Updated: Apr 27, 2026
Author Spotlight: Marmoset Research - Scope and Challenges
Published on: June 9, 2023
Spontaneous glomerular mesangial lesions in common marmoset monkeys (Callithrix jacchus): a benign non-progressive
Michael G Collins1, Natasha M Rogers, Shilpanjali Jesudason
1Central Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, SA, Australia; Transplant Immunology Laboratory, Basil Hetzel Institute for Medical Research, The Queen Elizabeth Hospital, Woodville, SA, Australia; School of Medicine, University of Adelaide, Adelaide, SA, Australia.
Background:
Common marmosets are known to develop an IgM glomerulopathy, which has been linked with 'wasting marmoset' syndrome. This study investigated renal pathology in a colony of marmosets, with and without weight loss.
Methods:
Renal histology, immunofluorescence, and electron microscopy were performed on marmosets euthanized for research or for weight loss. Serum and urine biochemistry were measured during life and at euthanasia.
Results:
Histology from 25 adult marmosets (19 research and 6 weight loss) showed mesangial expansion in the majority of glomeruli. Mesangial changes correlated with electron-dense deposits and IgM deposition by immunofluorescence; negligible other pathology was seen. Glomerular basement membrane thickness appeared increased compared to reported human measurements. Low-grade proteinuria was present in all animals, but did not progress. Renal function was normal in all animals.
Conclusions:
Marmosets develop a glomerulopathy characterized by mesangial expansion, IgM deposition, and proteinuria. This is a benign occurrence and not specifically associated with weight loss.
