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Interactions between CdTe quantum dots and DNA revealed by capillary electrophoresis with laser-induced fluorescence
Maja Stanisavljevic1, Jana Chomoucka, Simona Dostalova
1Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel University in Brno, Zemedelska, Czech Republic.
Abstract:
Quantum dots (QDs) are one of the most promising nanomaterials, due to their size-dependent characteristics as well as easily controllable size during the synthesis process. They are promising label material and their interaction with biomolecules is of great interest for science. In this study, CdTe QDs were synthesized under optimal conditions for 2 nm size. Characterization and verification of QDs synthesis procedure were done by fluorimetric method and with CE. Afterwards, QDs interaction with chicken genomic DNA and 500 bpDNA fragment was observed employing CE-LIF and gel electrophoresis. Performed interaction relies on possible matching between size of QDs and major groove of the DNA, which is approximately 2.1 nm.
