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Updated: Apr 27, 2026

High Throughput Yeast Strain Phenotyping with Droplet-Based RNA Sequencing

High Throughput Yeast Strain Phenotyping with Droplet-Based RNA Sequencing

Published on: May 21, 2020

Yeast as a budding technology in target validation.

Nathan Bays¹, Jonathan Margolis¹

¹Exelixis, Inc, 170 Harbor Way, P.O. Box 511, South San Francisco, CA 94083-0511, USA.

Drug Discovery Today. Technologies

|July 2, 2014

Summary

Yeast biology offers powerful tools for drug target validation. Researchers can use yeast models to study drug interactions, protein tracking, and receptor biology for new therapeutic development.

Area of Science:

Yeast biology
Eukaryotic cell biology
Drug discovery and development

Background:

Yeast (Saccharomyces cerevisiae) is a fundamental model organism for understanding eukaryotic cell biology.
It has a long history of enabling significant scientific discoveries and technological advancements.
Yeast genetics and cell biology are well-established, providing a robust foundation for research.

Purpose of the Study:

To review the application of yeast biology resources for validating drug targets.
To highlight how yeast models can elucidate drug-target interactions and aid in therapeutic development.
To discuss the utility of yeast for protein tracking, receptor characterization, and synergistic drug studies.

Main Methods:

Leveraging yeast genetic and biochemical techniques for target validation.

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Employing yeast as a system for high-throughput screening of drug interactions.

Utilizing yeast for studying protein localization and function.

Characterizing receptor biology within the yeast model.

Main Results:

Yeast resources facilitate the identification and validation of both mammalian and anti-fungal drug targets.
Studies in yeast can reveal synergistic effects between drugs and their targets.
Yeast enables facile methods for tracking proteins and characterizing receptor biology.
Web-based resources integrate vast literature on yeast biology, aiding research.

Conclusions:

Yeast serves as an invaluable and versatile platform for drug target validation and innovation.
The application of yeast biology accelerates the discovery and development of novel therapeutics.
Integrated web resources enhance the accessibility and utility of yeast-based research for drug discovery.