Related Experiment Video
Updated: Apr 27, 2026

Functionalization of Atomic Force Microscope Cantilevers with Single-T Cells or Single-Particle for Immunological Single-Cell Force Spectroscopy
Published on: July 10, 2019
Tapping, pulling, probing: atomic force microscopy in drug discovery
Justin Legleiter1, Tomasz Kowalewski1
1Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA.
Abstract:
The atomic force microscope is a versatile instrument that can image surfaces with nanoscale resolution, probe local mechanical properties, and measure a variety of interaction forces. It can be relatively easily operated in fluids, and thus experiments can be conducted under nearly physiological conditions, which is behind its numerous applications in biological problems. In the field of drug discovery, atomic force microscopy (AFM) presents a unique opportunity to study a variety of phenomena at the cellular and subcellular level, down to individual (macro)molecular complexes.:
Related Concept Videos
Atomic Force Microscopy
The AFM Probe
The probe is regarded as the heart of any AFM setup and comprises the...
Studying the Cytoskeleton

