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Comparative genetics of longevity and cancer: insights from long-lived rodents
Vera Gorbunova1, Andrei Seluanov1, Zhengdong Zhang2
1University of Rochester, Rochester, New York 14627, USA.
Abstract:
Mammals have evolved a remarkable diversity of ageing rates. Within the single order of Rodentia, maximum lifespans range from 4 years in mice to 32 years in naked mole rats. Cancer rates also differ substantially between cancer-prone mice and almost cancer-proof naked mole rats and blind mole rats. Recent progress in rodent comparative biology, together with the emergence of whole-genome sequence information, has opened opportunities for the discovery of genetic factors that control longevity and cancer susceptibility.
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