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Updated: Jan 26, 2026

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Accelerating lead development by microwave-enhanced medicinal chemistry
William D Shipe1, Scott E Wolkenberg1, Craig W Lindsley1
1Merck Research Laboratories, Department of Medicinal Chemistry, West Point, PA 19486, USA.
Abstract:
Microwave-assisted organic synthesis (MAOS) addresses the need for accelerated chemical synthesis by providing many advantages over classical thermal conditions. Microwave instruments produced by Biotage, CEM and Milestone enable chemistry to be safely and reproducibly performed on various scales and in a parallel fashion. To illustrate the high utility of this technology for lead development, our Akt kinase program will be described wherein MAOS played a pivotal role in the identification of isozyme-selective Akt inhibitors.:
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