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Discovery of structurally distinct tricyclic M4 positive allosteric modulator (PAM) chemotypes

Kayla J Temple1, Madeline F Long1, Julie L Engers1

  • 1Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

Bioorganic & Medicinal Chemistry Letters
|December 3, 2019
PubMed

Keywords:
M(4)Muscarinic acetylcholine receptorPositive allosteric modulator (PAM)Structure activity relationship (SAR)

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