Crevicular enzymes in peri-implant sulcus fluid around platform-switched implants: a pilot study

This study compared levels of the 2 crevicular enzymes-myeloperoxidase (MPO) and alkaline phosphatase (ALP)-in peri-implant sulcus fluid (PISF) around platform-switched implants (implant group) vs the 2 enzymes' levels in gingival crevicular fluid around contralateral natural teeth (control group). Twenty subjects were selected from a population who were set to receive fixed implant prostheses. Samples for PISF were collected at 3 different intervals: 1 week after the placement of a healing abutment, 1 week after the implant prosthesis was loaded, and 3 months post-treatment. Control group samples were taken at the same time points. The results from the implant group showed a statistically significant reduction in MPO levels from the first to the third collection, and a statistically significant increase in ALP levels over the 3-month post-treatment period, as compared to the control group.