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Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs

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Published on: January 17, 2020

Catalysis with complexes containing stereogenic metal centers.

E Peter Kündig¹

¹President Swiss Chemical Society, Department of Organic Chemistry, University of Geneva, 30 Quai Ernest Ansermet, CH-1211 Geneva 4, Switzerland. peter.kundig@unige.ch.

|July 2, 2014

Summary

Alfred Werner pioneered coordination complex stereochemistry, proving enantiomers exist. This study explores using stereogenic metal centers in asymmetric catalysis.

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Area of Science:

Coordination Chemistry
Stereochemistry
Asymmetric Catalysis

Background:

Alfred Werner, a founder of the Swiss Chemical Society and its first president, established the stereochemistry of coordination complexes.
Werner's Nobel Prize-winning work included demonstrating enantiomeric forms of cobalt(III) complexes, such as [Co(ethylenediamine)3][Cl3].

Purpose of the Study:

To examine the potential application of catalysts with stereogenic metal centers in asymmetric catalysis.
To build upon Werner's foundational work in stereochemistry.

Main Methods:

Review of existing literature on stereogenic metal centers.
Analysis of Werner's contributions to stereochemistry.

Main Results:

Coordination complexes can exhibit stereoisomerism, with enantiomeric forms.
Stereogenic metal centers are a key feature in chiral catalysts.

Conclusions:

Catalysts featuring stereogenic metal centers hold promise for asymmetric catalysis.
Werner's early work provides a crucial framework for understanding chiral coordination compounds.