Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Intellectual Disability01:29

Intellectual Disability

1.1K
Intellectual disability (ID) is a neurodevelopmental condition characterized by deficits in intellectual and adaptive functioning that manifest during the developmental period. This condition encompasses challenges in reasoning, memory, problem-solving, and learning, accompanied by impairments in everyday life skills, such as communication, self-care, and social interactions. Intellectual disability affects approximately 1% of the population in the United States, impacting an estimated 5...
1.1K
Karyotyping01:17

Karyotyping

49.1K
Overview
49.1K
Learning Disabilities01:25

Learning Disabilities

696
Learning disabilities are cognitive disorders caused by neurological impairments that affect cognitive functions like language and reading, without indicating overall intellectual or developmental challenges. These disabilities differ from global intellectual or developmental disabilities as they are limited to distinct cognitive functions. Common learning disabilities include dysgraphia, dyslexia, and dyscalculia, each of which impacts unique aspects of learning.
Dyslexia
Dyslexia is a...
696

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Minimally invasive pancreatectomy with mesentericoportal venous resection: Results from a French national cohort.

HPB : the official journal of the International Hepato Pancreato Biliary Association·2026
Same author

Decoding splicing variants in high-throughput sequencing: a functional validation approach integrating deep learning tools.

European journal of human genetics : EJHG·2026
Same author

The International Consortium for Arthrogryposis: A Collaborative Framework for Early Detection, Care, Research, and Education.

American journal of medical genetics. Part C, Seminars in medical genetics·2026
Same author

ARMC2 loss impairs cilia structure and leads to primary ciliary dyskinesia symptoms in mouse organs.

Frontiers in cell and developmental biology·2026
Same author

Predicting Best Performers After Minimally Invasive Left Pancreatectomy: Insights From a National Cohort.

Annals of surgery·2026
Same author

NFAT5: A Metabolic Time Capsule Encoding the History of Paternal Metabolic Oxidative Stress Within the Male Reproductive Tract.

Antioxidants (Basel, Switzerland)·2026

Related Experiment Video

Updated: Apr 27, 2026

Array Comparative Genomic Hybridization Array CGH for Detection of Genomic Copy Number Variants
09:16

Array Comparative Genomic Hybridization Array CGH for Detection of Genomic Copy Number Variants

Published on: February 21, 2015

19.4K

Array-CGH in children with mild intellectual disability: a population-based study.

Charles Coutton1, Klaus Dieterich, Véronique Satre

  • 1Laboratoire de Génétique Chromosomique, Département de Génétique et Procréation, Hôpital Couple Enfant, CHU Grenoble, 38700, Grenoble, France, CCoutton@chu-grenoble.fr.

European Journal of Pediatrics
|July 3, 2014
PubMed
Summary
This summary is machine-generated.

Array comparative genomic hybridization (array-CGH) identified genetic causes in 21% of children with mild intellectual disability (ID). This technique is crucial for diagnosing mild ID when other genetic causes are unknown.

More Related Videos

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

7.9K
Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization
16:37

Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization

Published on: August 5, 2008

12.5K

Related Experiment Videos

Last Updated: Apr 27, 2026

Array Comparative Genomic Hybridization Array CGH for Detection of Genomic Copy Number Variants
09:16

Array Comparative Genomic Hybridization Array CGH for Detection of Genomic Copy Number Variants

Published on: February 21, 2015

19.4K
A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

7.9K
Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization
16:37

Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization

Published on: August 5, 2008

12.5K

Area of Science:

  • Genetics
  • Developmental Biology
  • Medical Diagnostics

Background:

  • Intellectual disability (ID) is defined by impaired intellectual and adaptive functioning with childhood onset.
  • Chromosomal abnormalities are frequent causes of ID.
  • Array comparative genomic hybridization (array-CGH) has improved the diagnosis of genetic abnormalities in ID patients.

Purpose of the Study:

  • To investigate the genetic etiology of mild intellectual disability in children using array-CGH.
  • To assess the diagnostic yield of array-CGH in a population-based cohort of mild ID cases with previously unidentified genetic causes.

Main Methods:

  • Array comparative genomic hybridization (array-CGH) was performed on 66 children with mild intellectual disability.
  • Patients were selected from a population-based study with no previously identified genetic etiology.
  • Copy number variations (CNVs) were analyzed for their potential pathogenicity in relation to the ID phenotype.

Main Results:

  • One or more copy number variations (CNVs) were detected in approximately 30% (20/66) of children with mild ID.
  • Pathogenic or potentially pathogenic CNVs were identified in 14 children (~21%), with 8 (~12%) considered certainly responsible for the ID.
  • Array-CGH successfully identified the genetic etiology in a significant portion of previously undiagnosed mild ID cases.

Conclusions:

  • Array-CGH is clinically relevant for investigating the etiology of isolated idiopathic mild ID.
  • The diagnostic utility extends to cases with subtle dysmorphic features or congenital malformations.
  • This study highlights the importance of array-CGH in the genetic workup of mild intellectual disability.