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Increased serum levels of some inflammatory markers in patients with multiple sclerosis
S Uysal1, F Meriç Yilmaz, N Boğdaycioğlu
1Clinic of Biochemistry Ankara Numune Education and Research Hospital, Ankara, Turkey - dr_semauysal@hotmail.com.
Aim:
As known multiple sclerosis (MS) is a chronic neuroinflammatory progressive disease. The aim of this study was to assess some inflammatory markers in MS patients and their relationships with clinical subgroups and disability status.
Methods:
The serum levels of procalcitonin (PCT), YKL-40, IFN-γ and TNF-α were measured by an ELISA microplate reader in 59 MS patients and in 29 healthy subjects.
Results:
Mean serum PCT and TNF-α levels were significantly higher in patients with MS than control group (P<0.001). Serum YKL-40 and IFN-γ concentrations were elevated in MS group compared the healthy subjects, but the difference was not significantly. CIS, RRMS and SPMS groups had higher levels of PCT and TNF-α than control group. YKL-40 levels were positively correlated with EDSS score (r=0.412, P=0.001). IFN-γ and TNF-α levels were found to be negatively correlated with EDSS score (r=-0.347, P=0.007 and r=-0.328, P=0.011, respectively).
Conclusion:
Increased levels of these inflammatory markers might provide important contributions to the underlying inflammatory pathways in MS.
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