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Updated: Apr 27, 2026

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment

Published on: March 25, 2020

Atomically resolved tissue integration.

Johan Karlsson¹, Gustav Sundell, Mattias Thuvander

¹Department of Chemical and Biological Engineering, Chalmers University of Technology , Kemivägen 10 SE-412 96 Gothenburg, Sweden.

|July 4, 2014

Summary

This summary is machine-generated.

Atom probe tomography reveals direct inorganic bonding between calcium atoms and titanium oxide surfaces, supporting the osseointegration theory for implantable devices. This finding advances biomaterial development and in vitro evaluation techniques.

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Intact Histological Characterization of Brain-implanted Microdevices and Surrounding Tissue

Intact Histological Characterization of Brain-implanted Microdevices and Surrounding Tissue

Published on: February 11, 2013

Area of Science:

Biomedical Technology
Materials Science
Biomaterials

Background:

Understanding implant-tissue integration is crucial in biomedical technology.
The atomic-level interplay between biomaterials and biology during osseointegration is not fully understood.
Current theories define osseointegration as interfacial bonding, but experimental evidence is limited.

Purpose of the Study:

To investigate the atomic-level interactions at the implant-tissue interface.
To provide experimental evidence for the theory of osseointegration.
To explore the utility of atom probe tomography in studying biomaterial integration.

Main Methods:

Utilized atom probe tomography for three-dimensional atomic mapping.
Analyzed the interface between implanted titanium oxide and bone tissue.
Examined the presence and nature of interlayers at the atomic scale.

Main Results:

Demonstrated direct contact between calcium atoms and the titanium oxide surface.
Confirmed the absence of a protein interlayer, indicating a pure inorganic interface.
Provided the first experimental evidence supporting the accepted theory of osseointegration.

Conclusions:

Atom probe tomography is a powerful tool for elucidating implant-tissue interactions at the atomic level.
The formation of a pure inorganic interface experimentally supports the theory of osseointegration.
These findings will impact future biomaterial design and the development of in vitro evaluation methods.