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Updated: Apr 27, 2026

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT

Published on: August 4, 2018

Probes for optical imaging: new developments.

Kai Licha¹, Ute Resch-Genger²

¹mivenion GmbH, Robert-Koch-Platz 4, D-10115 Berlin, Germany.

Drug Discovery Today. Technologies

|July 4, 2014

Summary

This summary is machine-generated.

New fluorescent probes offer enhanced specificity and accuracy for molecular imaging beyond indocyanine green (ICG). This review explores advanced formulations like nanoparticles and targeted conjugates for clinical translation.

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Area of Science:

Biomedical imaging
Molecular probes
Nanotechnology

Background:

Indocyanine green (ICG) is an approved fluorescent dye with expanding applications.
Development of novel fluorescent probes is crucial for advancing molecular imaging.
Existing probes face limitations in specificity and accuracy for complex molecular events.

Purpose of the Study:

To review recent advancements in fluorescent probes beyond ICG.
To discuss various types of novel fluorescent probes and their mechanisms.
To critically assess the clinical translation potential of these advanced probes.

Main Methods:

Literature review of recent developments in fluorescent probe technology.
Categorization of probes based on formulation (nanoparticulate, targeted conjugates) and function (activatable, sensor, multimodality).
Analysis of advantages and limitations of each probe category.

Main Results:

Novel probes utilize diverse photophysical and biochemical mechanisms for improved molecular event monitoring.
Nanoparticulate formulations, targeted conjugates, activatable probes, sensor probes, and multimodality probes show promise.
Each probe type presents unique advantages and limitations impacting clinical utility.

Conclusions:

Advanced fluorescent probes offer higher specificity and accuracy compared to traditional agents like ICG.
Careful consideration of advantages and limitations is necessary for successful clinical translation.
Future research should focus on optimizing probe design for specific clinical applications.