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Psoriasis and bone mineral density: implications for long-term patients
Sara D'Epiro1, Chiara Marocco, Monica Salvi
1Dermatology and Venereology Policlinico Umberto I of Rome, University of Rome "Sapienza"
The Journal of Dermatology
|July 4, 2014
Summary
Psoriasis patients with longer disease duration are more likely to develop osteoporosis. Early bone metabolism evaluation is crucial for psoriasis patients, especially those with long-standing disease.
Area of Science:
- Dermatology and Rheumatology
- Bone Metabolism and Inflammatory Diseases
Background:
- Psoriasis is a chronic inflammatory condition linked to various comorbidities, including osteoporosis.
- Potential links include systemic inflammation, psoriatic arthritis (PsA), and certain psoriasis treatments.
Purpose of the Study:
- To evaluate bone mineral density (BMD) in psoriasis patients.
- To correlate osteopenia/osteoporosis prevalence with disease severity (PASI score), duration, PsA, and prior treatments.
Main Methods:
- Study included 43 psoriasis patients (19 with PsA).
- Assessed psoriasis severity (PASI), diagnosed PsA (CASPAR criteria, joint ultrasounds), and estimated disease duration.
- Bone density scans (dual-energy X-ray absorptiometry) of the lumbar spine and femoral neck were performed.
Main Results:
- Patients with osteopenia/osteoporosis had a significantly longer average psoriasis duration (17 years) versus those with normal BMD (8.8 years) (P=0.04).
- Linear logistic regression confirmed a significant association between mean disease duration and BMD alterations (P=0.04).
Conclusions:
- Longer psoriasis duration is a significant risk factor for reduced bone mineral density.
- Recommend early bone metabolism screening for psoriasis patients, particularly those with extended disease history.
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