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Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...
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Related Experiment Video

Updated: Apr 27, 2026

Mass Isolation and In Vitro Cultivation of Intramolluscan Stages of the Human Blood Fluke Schistosoma Mansoni
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Medullary schistosomiasis.

Lia Pappamikail1, Paulo Fernandes1, Casimiro Gonçalves1

  • 1Department of Neurosurgery, Centro Hospitalar de Lisboa Central EPE, Lisboa, Portugal.

Surgical Neurology International
|July 4, 2014
PubMed
Summary
This summary is machine-generated.

Schistosomiasis can cause spinal cord compression, mimicking tumors. Early consideration of this parasitic infection is crucial for accurate diagnosis and treatment in endemic regions.

Keywords:
Differential diagnosismedullary schistosomiasisoutcome

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Parasitology

Background:

  • Schistosomal infestation of the central nervous system is a rare but significant cause of spinal cord compression.
  • It is a predominant cause in schistosomiasis-endemic areas.

Observation:

  • A 38-year-old male from Ivory Coast presented with progressive paraparesis, neurogenic bladder, and sensory deficits.
  • MRI revealed a medullary lesion at D4-D5, initially suspected to be an intramedullary tumor.
  • Surgical excision and histopathology confirmed medullary schistosomiasis, not a glioma.

Findings:

  • Definitive histopathology established the diagnosis of medullary schistosomiasis.
  • The case highlights the challenge in differentiating parasitic infections from neoplastic lesions in the spinal cord.

Implications:

  • Medullary schistosomiasis should be considered in the differential diagnosis of transverse myelitis and cord compression.
  • Awareness is critical for patients from endemic regions or low socioeconomic backgrounds to ensure timely and appropriate management.