Short-Term Effects of Low-Level Red-Light Therapy on Central Retinal Function: A Combined Pattern ERG and Photopic...

Area of Science:

• Ophthalmology
• Retinal Physiology
• Photomedicine

Background:

• Low-level red-light therapy (RLRT) is being explored for myopia management.
• Its precise effects on retinal structure and function after repeated exposure require further investigation.

Purpose of the Study:

• To assess the immediate impact of RLRT on central retinal function in both myopic and non-myopic individuals.
• To analyze changes in retinal electrophysiology and structural parameters following RLRT exposure.

Main Methods:

• Thirty-six participants received RLRT (3 min and 1 min exposures).
• Retinal function was evaluated using pattern electroretinography (PERG) and photopic full-field electroretinography (Photopic 3.0 ERG).
• Structural measurements included axial length (AL) and choroidal thickness (CT).

Main Results:

• Myopic subjects showed a significant increase in PERG N35-P50 amplitude after 3 min of RLRT (p=0.013).
• Photopic 3.0 ERG indicated a trend towards increased b-wave amplitude in myopes after 3 min RLRT (p=0.06).
• Axial length and choroidal thickness showed correlations with specific electroretinography parameters in myopes post-therapy.

Conclusions:

• Short-term RLRT, especially 3-minute exposure, transiently enhances retinal function in myopic individuals.
• The study observed differential effects of RLRT between myopic and non-myopic groups.
• Findings suggest potential therapeutic benefits of RLRT for retinal function in myopia.