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The myofibroblast. Possible derivation from macrophages in xanthogranuloma
1Dermatopathology Section (Department of Dermatology), Boston University School of Medicine, Massachusetts 02118.
The American Journal of Dermatopathology
|June 1, 1989
Summary
Myofibroblasts, cells with dual fibroblast and smooth muscle traits, are found in various conditions. This study suggests human myofibroblasts may originate from macrophages, challenging previous fibroblast origin theories.
Area of Science:
- Cell Biology
- Histopathology
Background:
- Myofibroblasts exhibit characteristics of both fibroblasts and smooth muscle cells.
- Their presence is noted in diverse neoplastic and nonneoplastic conditions.
- The precise origin of myofibroblasts remains an area of active investigation.
Observation:
- A case of juvenile xanthogranuloma was examined using light and electron microscopy.
- Histological features were characteristic, though Touton giant cells were infrequent.
- Electron microscopy revealed lipid-laden macrophages containing myofibroblast-like fibrils.
Findings:
- The study observed macrophages containing transversely banded fibrils characteristic of myofibroblasts.
- These findings provide evidence supporting a macrophage origin for myofibroblasts.
- This contrasts with the established fibroblast derivation theory.
Implications:
- The findings suggest macrophages may be a source of myofibroblasts in humans.
- This has potential implications for understanding wound healing and fibrotic diseases.
- Further research is warranted to elucidate the cellular origins of myofibroblasts.