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Cutaneous anaplastic large cell lymphoma--a case report.
1Quest Diagnostics Incorporated, Cambridge, MA, USA. mahalinm@questdiagnostics.com
Indian Journal of Dermatology, Venereology and Leprology
|July 24, 2007
Summary
Anaplastic large cell lymphoma can affect the skin as primary or secondary disease. This case report highlights a solitary skin lesion as the initial sign of widespread systemic anaplastic large cell lymphoma.
Area of Science:
- Oncology
- Dermatology
- Pathology
Background:
- Anaplastic large cell lymphoma (ALCL) can manifest as primary cutaneous disease or secondary to systemic spread.
- Cutaneous involvement represents a spectrum of ALCL presentations.
Purpose of the Study:
- To report a case of systemic anaplastic large cell lymphoma presenting initially as a solitary cutaneous lesion.
- To illustrate the histological similarity between primary cutaneous ALCL and cutaneous involvement in systemic ALCL.
Main Methods:
- Case report detailing clinical presentation, diagnostic workup, and histological findings.
- Review of literature on cutaneous manifestations of ALCL.
Main Results:
- A solitary cutaneous lesion was the first clinical evidence of disseminated neoplastic disease.
- Histological examination of the cutaneous lesion was identical to primary cutaneous anaplastic large cell lymphoma.
Conclusions:
- Cutaneous lesions can be the initial presentation of systemic anaplastic large cell lymphoma.
- Histological features of cutaneous ALCL are consistent regardless of whether it is primary or secondary to systemic disease.
