Acantholytic Dyskeratosis Post-COVID Vaccination.

Area of Science:

• Dermatology
• Vaccinology
• Pathology

Background:

• Cutaneous side effects of COVID-19 vaccines are being increasingly documented.
• Acantholytic dyskeratosis is a rare histopathological finding.
• Grover disease (transient acantholytic dermatosis) is a benign skin condition.

Observation:

• An eruptive, erythematous, vesiculopapular rash developed post-Moderna COVID-19 vaccination.
• The patient had a prior history of Grover disease, which was in remission.
• Histopathology revealed patchy suprabasal acantholysis with dyskeratotic keratinocytes.

Findings:

• Histopathological findings mimicked Grover disease.
• Direct immunofluorescence was negative.
• The rash onset was temporally associated with vaccine administration.

Implications:

• This case highlights a rare potential cutaneous adverse event following mRNA vaccination.
• The Moderna vaccine may trigger or unmask Grover disease in susceptible individuals.
• Further research is needed to understand vaccine-associated dermatoses and their management.