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Related Concept Videos

Pore Transport and Ion-Pair Transport01:17

Pore Transport and Ion-Pair Transport

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Pore transport and ion-pair formation are critical mechanisms for the absorption and distribution of drugs in the body.
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited  but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct...
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One-Compartment Open Model for Extravascular Administration: First-Order Absorption Model01:15

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The first-order absorption model for extravascular administration describes the rate at which a drug is absorbed and eliminated, following the principles of first-order kinetics. This model is vital as it provides a mathematical representation of drug behavior within the body. It also allows for the prediction and interpretation of drug absorption and elimination based on the rate of change in drug concentration over time. This model can be visualized as a plasma concentration-time profile...
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One-Compartment Open Model for Extravascular Administration: Zero-Order Absorption Model01:12

One-Compartment Open Model for Extravascular Administration: Zero-Order Absorption Model

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Extravascular administration, such as oral or intramuscular routes, is a non-invasive drug delivery method, often preferred for ease and patient compliance. A key factor here is absorption, which dictates how quickly and effectively the drug enters the bloodstream from the administration site. Absorption follows either zero-order or first-order kinetics.
Zero-order absorption maintains a steady rate irrespective of the amount of drug left to be absorbed, making it a constant process. In the...
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Introduction to Membrane Traffic01:44

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The ER, Golgi apparatus, endosomes, and lysosomes work in tandem to modify, sort, and package proteins and lipids. An integrated membrane trafficking network facilitates the back and forth shuttling of molecules within different organelles in the same cell or across the cell membrane.
The transport of soluble and membrane proteins is mediated by transport vesicles that collect cargo from one cellular compartment and deliver it to another by fusing with the target organelle membrane. The Rab...
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Cellular Membranes and Drug Transport01:24

Cellular Membranes and Drug Transport

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Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
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The Significance of Membrane Transport01:44

The Significance of Membrane Transport

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The transport of solutes across the cell membrane is essential for metabolic processes, like maintaining cell size and volume, generating the action potential, exchanging nutrients and gases, etc. Membrane transport can be either passive or active. It can be simple diffusion, facilitated, or mediated transport aided by transport proteins such as transporters and channels.
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
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Related Experiment Video

Updated: Apr 27, 2026

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
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Virus-sized colloid transport in a single pore: model development and sensitivity analysis.

N Seetha1, M S Mohan Kumar2, S Majid Hassanizadeh3

  • 1Department of Civil Engineering, Indian Institute of Science, Bangalore 560012, India.

Journal of Contaminant Hydrology
|July 4, 2014
PubMed
Summary

A new mathematical model simulates virus-sized colloid transport and deposition in pores, revealing key factors like surface charge and flow velocity influence adsorption. This model aids in understanding colloid behavior at the pore scale for larger-scale predictions.

Keywords:
AdsorptionColloidsHydrodynamicsPore-scalePorous mediaVirus transport

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Area of Science:

  • Environmental Science
  • Colloid Science
  • Fluid Dynamics

Background:

  • Understanding colloid transport and deposition is crucial for various environmental and industrial processes.
  • Pore-scale phenomena significantly influence macroscopic transport behavior.
  • Existing models often simplify complex interactions within porous media.

Purpose of the Study:

  • To develop a comprehensive mathematical model for simulating virus-sized colloid transport and deposition in a cylindrical pore throat.
  • To investigate the influence of advection, diffusion, surface interactions, and hydrodynamic effects on colloid behavior.
  • To analyze the impact of various pore-scale parameters on colloid deposition and adsorption.

Main Methods:

  • Developed a mathematical model dividing pore space into bulk, diffusion, and potential regions.
  • Non-dimensionalized and numerically solved governing equations.
  • Conducted sensitivity analysis to identify key influencing parameters.

Main Results:

  • Colloid transport and deposition are highly sensitive to surface potentials, ionic strength, flow velocity, pore size, and colloid size.
  • Adsorbed concentration increases with decreasing surface potential ratio, increasing ionic strength, and increasing pore radius.
  • Colloid size significantly impacts deposition, with optimal deposition around 100nm particle radius.

Conclusions:

  • The model provides a detailed understanding of pore-scale colloid transport and deposition mechanisms.
  • Results offer insights into factors governing colloid adsorption and their dependence on system parameters.
  • The model serves as a foundation for upscaling colloid transport phenomena using Pore-Network Modeling.